First I´ld like to thank Serenity Dreams for her comment on my latest post about Propofol. :)
That gives me the go to explain the drug´s actions and interactions a bit more. I want you to know that everything I learned about Propofol is from an anesthesiologist with over 30 years of experience in this specific medical field.
As for me, information from a professional medical source, who´s dealing with Propofol every day for years, is way more reliable than "just" information from an instruction leaflet, attached to a drug.
Propofol is NOT offerend in any kind of oral form. The reason is simple, either it is broken down in the stomach or intestines or there´s no way to cross the internal borders to reach the bloodstream.
Based on Propofol´s composition (it´s an egg lecithin based emulsion) it most likely causes vomitting as soon as it gets into the stomach. If that´s not the fact and the stomach acids don´t work properly and destroy the drug (could be based on morbid changes), it will be destroyed when it gets from the stomach into the liver.
There´s no chance to ever get into the blood stream to cause the effect of sedation!
According to Dr. Murray´s defense team´s theory - that MJ swallowed Propofol, felt unconscious and died - they try to prove this by showing a pig´s reaction when it gets Propofol orally.
The significance is to prove whether or not Propofol would cause any effect by getting swallowed.....that´s the fly on the ointment. As explained before, Propofol is EFFECTLESS when used orally! So there is no way they are going to be able to prove that Propofol can be swallowed and become effective in the blood stream!
My personal opinion.....the story is just crap, or better said, some kind of distraction. ;)
Enjoy your weekend! :)
This is not correct information about egg lecithin.
AntwortenLöschenEgg Lecithin
Lecithin, sometimes referred to as phosphatidylcholine (PC), is a type of phospholipid that is used for a variety of purposes. It was first discovered in 1846 after French scientist Maurice Gobley extracted the compound from an egg yolk, but was only given its present name in 1850, coined from lekithos, Greek word for “egg yolk.” For several years after that, organic lecithin sold commercially was derived entirely from eggs.
As a powerful emulsifying agent and an additive that could extend the shelf life of processed foods, the commercial food industry used the product in baked goods, chocolates, salad dressings, nut butters, candies, protein drinks, instant soups, and prepared foods. Egg lecithin could also be added into recipes to improve flavor and to act generally as an emulsifier.
http://www.lecithinguide.info/organic-lecithin.html
There are several informative pages on the what Lecithin does in the body, the health benefits, treatments etc. Egg Lecithin would not cause vomiting. http://www.lecithinguide.info/index.html
The other drug that was found in the stomach does cause vomiting, unconsciousness, convulsions and possible death if ingested....Lidocaine.
A/R page 50: 0.13mg of propofol was found in the stomach contents but so was 1.6mg of Lidocaine.
These two drugs were not found at the scene already mixed together so that means that Michael would have had to either drink both separately or open both and mix them into his juice.
But this type of Lidocaine is a poison if ingested orally. There is an oral lidocaine but what was found at Carolwood is not this type.
A/R Page 7: Injectable Lidocaine HCI was found at the scene.
Material Safety Data Sheet - LIDOCAINE HCl INJECTION 1%
3. HAZARDS IDENTIFICATION
Hazard Description: Lidocaine HCl is classified as a poison by ingestion and intraperitoneal, intravenous, subcutaneous, intramuscular, and intratracheal routes. It is a local anesthetic. Lidocaine HCl affects the cardiovascular and central nervous systems, can cause skin and eye irritation, and is a possible sensitizer.
4. FIRST AID MEASURES
Ingestion:
DO NOT INDUCE VOMITING.
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open, and lay the victim on his/her side with the head lower than the body. Transport the victim IMMEDIATELY to a hospital.
http://www.safety.duke.edu/ohs/MSDS/Lidocaine_HCL.pdf
Lidocaine
Overdosage with lidocaine can be a result of excessive administration via topical or parenteral routes, accidental oral ingestion of topical preparations by children, accidental intravenous (rather than subcutaneous, intrathecal or paracervical) injection or prolonged use of subcutaneous infiltration anesthesia during cosmetic surgical procedures. These occurrences have often led to severe toxicity or death in both children and adults. Lidocaine and its two major metabolites may be quantified in blood, plasma or serum to confirm the diagnosis in potential poisoning victims or to assist in the forensic investigation in a case of fatal overdosage.
http://en.wikipedia.org/wiki/Lidocaine#Overdosage
Honeytania said: As for me, information from a professional medical source, who´s dealing with Propofol every day for years, is way more reliable than "just" information from an instruction leaflet, attached to a drug.
AntwortenLöschenThe information does not come from "just a leaflet attached to a drug" but from the Material Data Sheet which is required by law for the safe handling, first aid instructions etc of a product. This data is reviewed by those using the propofol 9or other chemicals) such as anesthesiologists, doctors etc.
Material Data Sheet
A material safety data sheet (MSDS) is a form with data regarding the properties of a particular substance.
An important component of product stewardship and workplace safety, it is intended to provide workers and emergency personnel with procedures for handling or working with that substance in a safe manner, and includes information such as physical data (melting point, boiling point, flash point, etc.), toxicity, health effects, first aid, reactivity, storage, disposal, protective equipment, and spill-handling procedures. MSDS formats can vary from source to source within a country depending on national requirements.
MSDS (material safety data sheets) are a widely used system for cataloging information on chemicals, chemical compounds, and chemical mixtures. MSDS information may include instructions for the safe use and potential hazards associated with a particular material or product. These data sheets can be found anywhere where chemicals are being used.
There is also a duty to properly label substances on the basis of physico-chemical, health and/or environmental risk. Labels can include hazard symbols such as the European Union standard black diagonal cross on an orange background, used to denote a harmful substance.
An MSDS for a substance is not primarily intended for use by the general consumer, focusing instead on the hazards of working with the material in an occupational setting.
In some jurisdictions the MSDS is required to state the chemical's risks, safety, and effect on the environment.
It is important to use an MSDS specific to both country and supplier, as the same product (e.g. paints sold under identical brand names by the same company) can have different formulations in different countries. The formulation and hazard of a product using a generic name (e.g. sugar soap) may vary between manufacturers in the same country.
http://en.wikipedia.org/wiki/Material_safety_data_sheet
I didn´t say that egg lecithin causes the vomitting, I just said, it´s based on that emulsion. Propofol most likely causes vomitting because of its chemical composition not just because it´s egg lecithin based.
AntwortenLöschenAs I posted before, my information is from a physician with a lontime experience on that particular medical field.
I´m very sure, she didn´t lie to me or gave me wrong information about Propofol.